Systems Biology and Physiome Projects
نویسندگان
چکیده
منابع مشابه
Predictive Modeling and Integrative Physiology: The Physiome Projects.
The fundamental paradigm in physiological research is integration. Biological researchers are now ready to define for a species a mathematical construct, the Physiome, the all-encompassing quantitative model of an organism. The goal of the human Physiome project is improved health care, through deep understanding of the organism, all the way down to the genes, reconciling contradictions and cla...
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Predicting information about human physiology and pathophysiology from genomic data is a compelling, but unfulfilled goal of post-genomic biology. This is the aim of the so-called Physiome Project and is, undeniably, an ambitious goal. Yet if we can exploit even a small proportion of the rich and varied experimental data currently available, significant insights into clinically important aspect...
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Good accessibility of publicly funded research data is essential to secure an open scientific system and eventually becomes mandatory [Wellcome Trust will Penalise Scientists Who Don't Embrace Open Access. The Guardian 2012]. By the use of high-throughput methods in many research areas from physics to systems biology, large data collections are increasingly important as raw material for researc...
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Advances in the in vitro synthesis and evolution of DNA, RNA, and polypeptides are accelerating the construction of biopolymers, pathways, and organisms with novel functions. Known functions are being integrated and debugged with the aim of synthesizing life-like systems. The goals are knowledge, tools, smart materials, and therapies.
متن کاملPerspectives of physiome research
Physiome is an area of physiology to generate a whole system by analyzing and integrating scattered and discrete information. The term "physiome" was first introduced by James B. Bassingthwaight in 1993, and officially announced by the International Union of Physiological Societies as the new field to be accomplished in the 21st century. In this review, I introduce the concepts of physiome, why...
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ژورنال
عنوان ژورنال: Wiley Interdisciplinary Reviews: Systems Biology and Medicine
سال: 2009
ISSN: 1939-5094,1939-005X
DOI: 10.1002/wsbm.67